Welcome

 Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.

 

map resolution statistics

A major goal of the EMDataResource team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004),  CryoEM Modeling Challenge (Ludtke et al 2012),  CTF Challenge (Marabini et al 2015), Map and Model Cryo-EM Challenges (Lawson & Chiu 2018), and most recently the 2019 Model Metrics Challenge (Lawson et al in press).

News

Map Challenge Assessment Update

Map Challenge Assessors:

  • If you have not yet completed your analysis, the deadline for submitting assessment reports is now end of April (April 30). After that time we will be releasing the masked software/submitter info.
  • We are working on the planning for a two day face-to-face discussion of assessment results, and are considering several possible dates/locations either over the summer or (more likely) in September.
  • Following the workshop each assessor/assessment group will have the opportunity to publish their findings in a journal special issue.

Model Challenge Comparison Site

The model challenge assessment period is still in progress.  Interested to see how we the results are being assessed?  Please visit the model-compare pages at http://model-compare.emdatabank.org.  There you can view and compare the submitted models via more than a dozen different whole-model and residue level metrics, as summarized here.

Map Challenge Webinar

As a reminder the Blind Assessment phase of the EMDataBank Map Challenge.is now open. A 1 hour webinar held on November 17 @15:00 UTC (9:00 US-CT, 10:00 US-ET, 15:00 UK, 16:00 Eur, 23:00 China) covered these topics:

  • map challenge submissions overview
  • how the submitted data and files were prepared for blind assessment
  • how to download/access the data
  • what preliminary analyses are already available
  • how to participate in the assessment phase
  • Q/A period

You can view/listen to the recorded webinar here:

 

 

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EMDataResource Validation Challenges are supported by NIH National Institute of General Medical Sciences

Please send your challenge questions, comments and feedback to challenges@emdataresource.org

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