Welcome

IMPORTANT NOTICE: This website will be deprecated in late September 2024.  At that time, the URL challenges.emdataresource.org will redirect to emdataresource.org/challenges.

Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.

 

map resolution statistics

A major goal of the EMDataResource team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004),  CryoEM Modeling Challenge (Ludtke et al 2012),  CTF Challenge (Marabini et al 2015), Map and Model Cryo-EM Challenges (Lawson & Chiu 2018),  the 2019 Model Metrics Challenge (Lawson et al 2021).

News

Joint Challenges Wrap-Up Meeting Oct 6-8

In 2016 EMDataBank ran two community challenges in parallel to create awareness of the need for cryoEM structure validation as a routine process in research studies and publications, and to expedite development of quantitative tools for assessment

Model Challenge Face-to-Face Meeting

Update for the Model Challenge: A face-to-face meeting was held Monday May 29, 2017 to discuss model assessments and how to move forward with completing the challenge.  The challenge has been designed to enable assessment of current approaches to interpretation of higher resolution (3-5Å) cryoEM maps with atomic models, to critically evaluate the map interpretation, model fitting, model refinement, and validation methods that are now coming into use. Initial assessments of the 106 submissions from 16 modellers have been prepared and can be viewed at the model comparison site.  Notes from the May 29 meeting are available in the provided attachment.

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EMDataResource Validation Challenges are supported by NIH National Institute of General Medical Sciences

Please send your challenge questions, comments and feedback to challenges@emdataresource.org

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