Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.


map resolution statistics

A major goal of the EMDataResource team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004),  CryoEM Modeling Challenge (Ludtke et al 2012),  CTF Challenge (Marabini et al 2015), Map and Model Cryo-EM Challenges (Lawson & Chiu 2018), and most recently the 2019 Model Metrics Challenge (Lawson et al in press).


Announcing the 2021 Ligand Model Challenge

February 1, 2021: Our next model challenge launches today: the 2021 EMDataResource Ligand Model Challenge. The task for modeler teams in this round is to optimize reference models against selected target maps containing protein or protein+RNA, ligands, ions and solvent (1.9-2.5 Å resolution range). 

2019 Model Metrics Challenge Outcomes Preprint

June 15 2020: "Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution" is available as a preprint at BioRxiv while under consideration for publication.  Feburary 2021 update: The final version of the paper is now published in Nature Methods with an accompanying News & Views commentary.

2019 Model Metrics Challenge

EMDataResource is trying something new and has put together a smaller, shorter-timeline EM model challenge. The deadline for submission of completed models fitted to target maps (2-3 Å resolution range) is May 25  May 28 (3 PM US Eastern). If you are interested in submitting models for this challenge please send us an email (challenges@emdataresource.org).


EMDataResource Validation Challenges are supported by NIH National Institute of General Medical Sciences

Please send your challenge questions, comments and feedback to challenges@emdataresource.org

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